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Tough question as I'd want to know the gig but equally with a stripped down rig I'm happy with anything as the setup in itself is a fun challenge to extract tone and variety. I've done many gigs this way in small clubs - typically with a Mesa Boogie Studio 22 and either a tele or a strat (because the other guitarist used a Les Paul).
Give me a Les Paul and any decent tube combo and I'll take it but lean towards a classic voiced Marshall or Fender. I'd genuinely be happy turning up to a local gig with my Fender Blues Junior and a Les Paul and expect to rock it, but a boost pedal would be nice!
I own a lot of amps but none that would be loud enough for some gigs but quiet enough for others, other than my Mesa DC2 1x12 combo. I got it with an 1X12 extension cab that I use for bigger venues. So it would probably be that amp and my Zemaitis SUJ101 LTD13. The guitar has big fat single coil DeArmond styled MR2000B pickups in it that I could get most of my favorite tones out of.
Guitar: My 1995 R9 (modified with old Gibson PAFs, a double white @ 8.5Ω in the bridge, double black @ 7.5Ω in the neck, Luxe caps, all else stock.)
Amp: My 1989 Mesa Boogie MK III (walnut & wicker 1x12 combo, Simul-class, [4-power tubes], Black widow, no 5-band EQ.)
Really, it's all I've ever needed...but don't tell that to my wife! :salude